Assistant Professor
Pediatric Blood and Marrow Transplantation
The goal of our research is to understand how the hematopoietic stem cells (HSCs), their clonal composition and competition, and their progeny affect initiation of blood disorders. Early-onset clonal hematopoietic disorders, including malignant diseases like pediatric MDS or acute myeloid leukemia, are states of significant disturbance of the balanced clonal output. Origins of these early-onset diseases are poorly understood, but likely involve developmental acquisition of mutations that shape hematopoiesis over years.